Research
We consider the physiological state of the patient in response to trauma. The ultimate goal of our work is to create a validated whole-body physiological digital twin of a patient + injury profile. Once constructed we want to ask questions about treatment protocols, intervention timing and cohort studies of in-silico clinical trials. In addition, we aim to provide the most well-validated computational model of the patient for robust, dynamic, high-fidelity healthcare simulation training.
Highlighted
A Whole-Body Mathematical Model of Sepsis Progression and Treatment Designed in the BioGears Physiology Engine
Frontiers in Physiology
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01 Oct 2019
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https://doi.org/10.3389/fphys.2019.01321
Describing the development of a sepsis model and the physiologic response within the BioGears framework.
All
2024
Increasing Realism and Variety of Virtual Patient Dialogues for Prenatal Counseling Education Through a Novel Application of ChatGPT: Exploratory Observational Study
JMIR Medical Education
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01 Feb 2024
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doi:10.2196/50705
2023
Whole Body Physiology Model to Simulate Respiratory Depression of Fentanyl and Associated Naloxone Reversal - A Model Informed Repeat Dosing Analysis
Research Square Platform LLC
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22 Nov 2023
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doi:10.21203/rs.3.rs-3527636/v1
Increasing Realism and Variety of Virtual Patient Dialogues for Prenatal Counseling Education Through a Novel Application of ChatGPT: Exploratory Observational Study (Preprint)
JMIR Publications Inc.
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17 Jul 2023
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doi:10.2196/preprints.50705
Whole Body PBPK Model of Nasal Naloxone Administration to Measure Repeat Dosing Requirements During Fentanyl Overdose
Cold Spring Harbor Laboratory
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25 Apr 2023
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doi:10.1101/2023.04.24.538032
2021
Detecting Patient Health Trajectories Using a Full-Body Burn Physiology Model
BioMedInformatics
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02 Nov 2021
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doi:10.3390/biomedinformatics1030009
A multiscale computational model of angiogenesis after traumatic brain injury, investigating the role location plays in volumetric recovery
Mathematical Biosciences and Engineering
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01 Jan 2021
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doi:10.3934/mbe.2021161
2020
BioGears: A C++ library for whole body physiology simulations
Journal of Open Source Software
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14 Dec 2020
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doi:10.21105/joss.02645
BurnCare tablet trainer to enhance burn injury care and treatment
BMC Emergency Medicine
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30 Oct 2020
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doi:10.1186/s12873-020-00378-z
2019
A Whole-Body Mathematical Model of Sepsis Progression and Treatment Designed in the BioGears Physiology Engine
Frontiers in Physiology
·
01 Oct 2019
·
https://doi.org/10.3389/fphys.2019.01321
Describing the development of a sepsis model and the physiologic response within the BioGears framework.
A Full-Body Model of Burn Pathophysiology and Treatment Using the BioGears Engine
2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
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01 Jul 2019
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doi:10.1109/embc.2019.8857686
Open Source Pharmacokinetic/Pharmacodynamic Framework: Tutorial on the BioGears Engine
CPT: Pharmacometrics & Systems Pharmacology
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01 Jan 2019
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doi:10.1002/psp4.12371
2015
Neuromechanical pumping: boundary flexibility and traveling depolarization waves drive flow within valveless, tubular hearts
Japan Journal of Industrial and Applied Mathematics
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27 Oct 2015
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doi:10.1007/s13160-015-0195-3
A Mathematical Model and MATLAB Code for Muscle–Fluid–Structure Simulations
Integrative and Comparative Biology
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03 Sep 2015
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doi:10.1093/icb/icv102
2014
Numerical Study of Scaling Effects in Peristalsis and Dynamic Suction Pumping
Biological Fluid Dynamics: Modeling, Computations, and Applications
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01 Jan 2014
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doi:10.1090/conm/628/12543